Propagation of Epileptiform Activity on a Submillimeter Scale

Modeling the onset and propagation of epileptiform activity in children

In epilepsy of childhood, diagnosis of a focal origin is crucial for therapeutical decisions. As a noninvasive method, MEG may supplement the information obtained during EEG video monitoring. Since MEG provides a higher sensitivity for interictal events, the task of source modeling is manifold: a) localize potential irritative onset zones in MEG; b) localize interictal onset and propagation in ...

Enhanced propagation of epileptiform activity through the kindled dentate gyrus.

Extracellular recordings were performed in combined hippocampal-entorhinal cortex (HC-EC) slices obtained from control and commissural kindled rats to investigate the propagation of epileptiform activity from the entorhinal cortex (EC) to the hippocampus (HC) after chronic epilepsy. Lowering extracellular Mg2+ concentration in control slices induced epileptiform activity consisting of spontaneo...

Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices.

1. Spontaneous non-synaptic epileptiform activity was induced by bathing rat hippocampal slices in low-Ca(2+) solution. Extracellular recordings from electrodes placed on both sides of a complete cut showed that non-synaptic activity was synchronized across the lesion. 2. Ion-selective electrode recordings showed that each event was accompanied by a transient increase in extracellular potassium...

Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intrac...

Wireless Sensing of Epileptiform Activity